My three "Is the virus real?" articles from 2020 and 2021
Several readers demanded I supply the goods, so here they are. Enough for me on this.
Tuesday, October 13, 2020
The testing mess, lack of reliable data on Covid-19, and a hypothesis why
UPDATE: According to Eric Schneider, MD in the July 25 NEJM, page 300, "The most recent congressional rescue package features $25 billion for testing." So, in the absence of regulation, if you wanted to make a quick killing, all that was needed was to develop a Covid test and offer it in the US between March and October. Read on.
On January 5 the Chinese scientist who sequenced the first known SARS-2 genome uploaded it to a US database and to the WHO. Within the first 10 days of January a sequence for the Chinese SARS-CoV-2 virus was widely circulated by Edward Holmes of Australia. (He coauthored the March Nature Medicine commentary I criticized here and here.) Holmes works closely with Chinese scientists who passed the sequence to him, possibly without CCP authorization. Here the GISAID international database explains the origin of its reference SARS-CoV-2 strain.
People were able to immediately start devising PCR tests based on the deposited sequences, even without an actual virus.
After that, as the virus' range extended, scientists around the world started isolating the virus. There have been many thousands of isolations from patients from many countries, and scientists have decoded the genome, i.e., sequenced the virus, and shown which mutations are occurring when, in different parts of the world. Alina Chan helped create a website that characterizes these strain differences by location, based on sequences uploaded to public databases by scientists around the world.
The virus has been cultured in many countries, as early as January-February, including by CDC:
1. Akst J. Australian Lab Cultures New Coronavirus as Infections Climb. The Scientist. https://www.the-scientist.com/news-opinion/australian-lab-cultures-new-coronavirus-as-infections-climb-67031.
2. CDC has grown the COVID-19 virus in cell culture, which is necessary for further studies, including for additional genetic characterization. The cell-grown virus was sent to NIH’s BEI ResourcesRepository for use by the broad scientific community.
But the virus cannot be cultured in ordinary hospital labs, because SARS is a designated biological warfare "Select" agent with pandemic potential and must (by US law) be cultured only in high containment laboratories. So culture tests are not now commercially available, but they are being performed under specified conditions.
Testing for the virus is a disaster. There are 186 tests for which FDA has issued emergency use authorizations (PCR, Antibody, and Rapid Antigen tests) that have been in use. I discussed the antibody testing disaster here. Today I focus on the PCR test disaster.
The CDC made the inexplicable decisions to restrict US testing by allowing only the test CDC had developed to be used, throughout January and February. It was a test that was both unnecessarily cumbersome, and faulty. Perhaps because CDC was well aware of the problems, as many labs had pointed them out, CDC would agree to test only those who almost certainly were infected. This harmed lots of patients, and allowed the virus to spread silently for a long time. It further slowed down the development of better and more accessible tests by private, university and state public health labs. CDC's ban on other tests was only lifted on February 28. (Tom Frieden, former CDC Director, has called for an independent panel to investigate what went wrong.)
(The CDC link below no longer takes you to this CDC graph, which shows how few tests CDC performed during those first two months.)
Number of specimens tested for SARS-CoV-2 by CDC labs (N=3,995) and U.S. public health laboratories* (N=15,749)†
Possibly germane is the fact that CDC's Covid response was managed by Lisa Messonier, MD, who is Rod Rosenstein's sister. (Rosenstein is the former Deputy Attorney General who, according to the NYT, discussed wearing a wire to record President Trump and suggested that cabinet members consider using the 25th Amendment against Trump.)
By Feb 29, the FDA said it would allow companies to apply for an emergency use authorization (EUA) for their tests, but the procedure was so complicated that only 6 entities applied over the first week. By the middle of March we still didn’t have many tests in the US, so the FDA then said anyone who had developed a test could offer it, without any review, and subsequently send the FDA information on the test performance. This was a
By late March there was an explosion of tests being offered, but nobody had any idea how they compared with each other, nor how sensitive nor specific they were, apart from their manufacturers' claims.
After a while, FDA realized that many of these tests were worthless, and they took a number of tests made in China off the market, but left the others, still over 100 tests. On October 8, FDA announced it would no longer review (and issue) more EUAs for Covid lab tests, in order to "make the best use" of agency resources.
There are no reliable numbers I know of for how well these tests have performed relative to any gold standard. (There is no gold standard yet.)
Part of the problem is the virus itself. It doesn’t always stimulate the antibodies that labs are looking for, and some people who get Covid do not make those antibodies in sufficient quantity to be measured. There were similar problems with SARS-1 tests, although, since this virus causes higher nasopharyngeal titers than SARS-1, PCR and antigen tests ought to be more sensitive. Also, SARS-1 caused 8,000 total cases and SARS-2 750 million, so you would have expected some of those issues to be resolved by now.
As far as the PCR tests go, it was hoped they would be the gold standard but it has not worked out that way. There are many potential problems with PCR tests. The target nucleotide sequence that is chosen may not be totally specific to this virus, and cross react with sequences from other microorganisms or ?
A number of different primers (approximately 20 nucleotide long sequences) have been selected for use by different companies. "Laboratories have used different combinations of primers and probes, while some laboratories do not disclose the targets or sequences of their primers/probes..." We don’t know how they compare with each other. Different machines are being used. Different cycle lengths, i.e., number of doubling cycles, are used in different labs. The different tests have widely varying limits of detection, by 3 plus orders of magnitude. Furthermore, potential lab contamination is always an issue with PCR tests, which can cause false positives. Finally, PCR tests are widely acknowledged to pick up false positives from viral debris, for up to 3 months after patients cease to be infectious.
If the sample is not obtained carefully, or if it is obtained too early or too late in the course of the illness, the amount of virus on the swab may not reach the limits of detection of the test.
There is another big wrinkle, when you don't have a near-perfect test, which is termed the "pretest probability." I have not figured out a way to explain it simply. Basically, if a patient has Covid symptoms and SARS-2 is present in the community, a positive test is likely to be accurate. But if patients don't have SARS-2 symptoms, and/or there is a very low level of SARS-2 circulating, then, of course, truly positive individuals are rare. In this situation, false positive test results may be more common than true positives. The less likely a person is to have a infection, the more likely that a positive test result will be false.
Can the rates of false positives and false negatives be calculated? Not with the data that are currently publicly available. I doubt CDC and FDA can, either.
The FDA posted a website on October 7 in which FDA says it sent out small test kits to dozens of companies and labs that developed tests, to see how the tests/labs perform. Many labs did not return the results to FDA:
A basic metric for all infectious diseases is the proportion of infected but asymptomatic cases. Generally these cases develop immunity. When the WHO has estimated that over 10% of the world's population (>780 million cases) has been infected, surely the great majority have been asymptomatic. I say this because the WHO says 38 million cases of Covid have been reported, which is under 5% of WHO's estimated number of cases. Yet we still have no reliable information on the % of asymptomatics, nor of the % of immunes.
In both the US and the world, cases are rising, but deaths are not. Death rates in hospitalized patients are a small fraction of what they were. This tells us that the virus is less lethal than it was, and/or treatment has improved, and/or the rise in cases is, at least in part, due to the massive numbers now being tested (about 1 million people per day in the US). Often, asymptomatic people are being screened, found positive, and designated as cases. My county had an 'outbreak' of Covid in migrant workers who were screened during the blueberry harvest, yet none had symptoms. We need to know if these positive but asymptomatic people are infectious, but currently we cannot reliably tell. Perhaps if we knew how many PCR cycles it took for them to produce a positive result, we could estimate the amount of virus present and make an educated guess about infectivity. However, the labs are not required by FDA to provide this information, and they don't.
Coupled with the above confusion is the fact that the media have given us misinformation about most aspects of the pandemic. Not only is the public confused by this testing mess, and the unwillingness of our public health agencies to commit themselves regarding the validity and meaning of test results, and making sure only quality tests are being used. We are also befuddled about who gets sick, who gets chronic covid, and why certain treatments have been suppressed while others have been pushed, despite the absence of supportive data. What exactly are the patterns of age, disease severity and preexisting conditions in Covid patients? What is the evidence that masking and social distancing have worked in the US? Why does CDC say to maintain a 6 foot distance while WHO says 3 feet is enough? A Reuters article noted:
China, Denmark, France, Hong Kong and Singapore recommend social distancing of 1 meter, and many people also choose to, or are required to, wear face masks in public spaces.
Australia, Belgium, Greece, Germany, Italy, Spain and Portugal advise people to keep 1.5m apart. Switzerland this week also reduced the required distance to 1.5m from 2m.
I conclude that we are being played by the government and the media, and every piece of information they present to us I now scrutinize for an ulterior motive, which is often to ramp up the fear of Covid-19.
If you look at the suppression of effective treatments, the falsely elevated case and death numbers, and the prolonged lockdowns which make little sense--because this is a disease that can be effectively treated, even without remdesivir and vaccines, and which, at this point in time, seems to have mortality similar to influenza (2 in 1,000 cases)--you realize we are being subjected to a wholly different agenda than what is claimed.
We are being made to think this pandemic is much more severe than it really is, and the powers that be are doing their best to prolong the emergency. For example, Tony Fauci finds it a challenge to sufficiently scare the public:
"The wide range of clinical manifestations of the disease ... makes conveying the dangerousness of Covid-19 incredibly challenging," Fauci said in an October 13 interview with STAT.
Our economies are being destroyed and many jobs will never come back. (US 2nd quarter GDP declined 33%, on par with the Great Depression.)
There is a meme that has been used by leaders of multiple countries and the World Economic Forum, and that is “Build back better."
My best current hypothesis is that the World Economic Forum and its ilk are using the pandemic as a means to destroy the current economy, impoverish many millions of people, and rebuild and finance it to their own specifications.
They are using terms like: preventing climate change, green, save the earth, biodiversity, sustainability, non-racist, equitable, fair-- to sweeten the image of what is to come.
Which seems to be a surveillance state with increased top down control and a reduced standard of living. Green goals may be part of it; after all, the leaders need pristine forests and fields for their own use. Maybe, or maybe not, for our use.
This view is consistent with statements by Peter Daszak, CEO of EcoHealth Alliance, who is associated with WIV, NIAID, DOD and facilitated transfers of bat coronaviruses found around the world to scientific and military labs. Quoted in the WaPo, “Pandemics as a whole are increasing in frequency,” said Peter Daszak, a disease ecologist who is president of EcoHealth Alliance, a public health organization [a charitable way to describe his organization--Nass] that studies emerging diseases. “It’s not a random act of God. It’s caused by what we do to the environment."
Daszac told Slate, "I’ve found that things like land use, change, deforestation, road building, mining, and agricultural intensification are the reasons we push ourselves into wildlife habitat and get infected."
Peter Horby, co-director of the Recovery trial in the UK, which poisoned people with HCQ to prevent its use for Covid, recently tweeted, "this is where we should be headed" regarding a video on bicycle commuting produced by the World Economic Forum. The NYT and other outlets have run similar pieces on how human incursions into nature are destroying nature and producing pandemics. In August, Tony Fauci and David Morens, in CELL, wrote,
"in a human-dominated world, in which our human activities represent aggressive, damaging, and unbalanced interactions with nature, we will increasingly provoke new disease emergences. We remain at risk for the foreseeable future. COVID-19 is among the most vivid wake-up calls in over a century. It should force us to begin to think in earnest and collectively about living in more thoughtful and creative harmony with nature..."
The pandemic and prolonged lockdowns, which are huge overreactions to the actual seriousness of the illness, coupled with suppression of effective treatments, appear to be the means to get us to the "new normal" aka "Great Reset".
UPDATE October 17: Not sure there is another agenda here? Why is the World Economic Forum launching a health passport that could be required to travel? The Commons Project Foundation and the World Economic Forum announced the launching of international trials for CommonPass, a digital health pass for travelers to securely verify their COVID-19 test status. The project's chief medical officer is Bradley Perkins, a former CDC doctor who was an expert on biological weapons, but could not find any anthrax at the AMI building in Florida, telling staff to continue working there for several days before gross contamination was discovered. “Without the ability to trust COVID-19 tests - and eventually vaccine records - across international borders, many countries will feel compelled to retain full travel bans and mandatory quarantines for as long as the pandemic persists,” said Dr. Bradley Perkins, Chief Medical Officer of The Commons Project. Which was launched a couple of years ago with funding from the Rockefeller Foundation.
Tuesday, January 5, 2021
Is the virus real? Has it been photographed? What about Koch's postulates? What to do?
Even though I thought I had answered these questions, smart people who I respect keep asking if the virus is real. So here is another stab at explaining this.
Yes, the virus is real. A misleading CDC/FDA document originally written in February but reposted months later stated there was no "quantifiable" sample of SARS-CoV-2 available. While it might have been true in early February, it has been false since then. Here, CDC tells you how they cultured SARS-CoV-2 and how you can get some--as long as your institution satisfies stringent criteria. CDC's discussion of its culture technique was published in its own journal, Emerging Infectious Diseases. The article concludes:
We have deposited information on the SARS-CoV-2 USA-WA1/2020 viral strain described here into the Biodefense and Emerging Infections Research Resources Repository, ATCC and the World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, to serve as the SARS-CoV-2 reference strain for the United States. The SARS-CoV-2 fourth passage virus has been sequenced and maintains a nucleotide sequence identical to that of the original clinical strain from the United States. These deposits make this virus strain available to the domestic and international public health, academic, and pharmaceutical sectors for basic research, diagnostic development, antiviral testing, and vaccine development. We hope broad access will expedite countermeasure development and testing and enable a better understanding of the transmissibility and pathogenesis of this novel emerging virus.
This virus has been isolated and fully sequenced 125,000 times in countries around the world, both by poor countries such as Nepal, as well as by richer countries such as South Korea and Australia. The methods are described, sometimes in an accessory file.
A large number of people who don't know a lot about viruses, but were cognizant of the nonsense the public is being fed about most other aspects of the Covid-19 pandemic, understandably concluded there was no virus. Perhaps the government agencies that supplied the information from which they drew this conclusion did so cunningly, with the hope to entrap the unwary.
Thankfully, a New Zealand microbiology professor explains what took place as a result of poor wording in requests for information.
Some people still clamour that Koch's Postulates have not been met wrt SARS-CoV-2--but they were met, as closely as possible, in animal models like the Golden Syrian hamster. [Why are the Syrians always getting slammed?] You can't infect a human to test Koch's postulates, and then publish it, and not be arrested.
What about photomicrographs of SARS-CoV-2? It turns out that some of the early photographs were misinterpretations by their authors and did NOT, in fact, provide reliable pictures of the virus. See this Correspondence in the Lancet about published photomicrographs that mistook endoplasmic reticulum for virus, for instance. (Strangely enough, two of the coauthors of the fabricated Lancet paper damning chloroquine and hydroxychloroquine were coauthors of this Lancet article and response that interpreted photos of the virus incorrectly: Mandeep Mehra and Frank Ruschitzka. They admitted no mistakes either time. I wonder if the Lancet will give them a 3d chance?)
But it seems that good pictures of the virus have been taken. For instance, see figure 2 in this paper.
Please look at the links above before dismissing the virus. We have been given misinformation about masks, lockdowns, tests, case numbers, deaths, asymptomatic spread, duration of immunity, proper treatment, etc. But there truly is a mean new virus out there. It looks like some nasty features were engineered in.
There is Good News
We have vitamins, minerals, and drugs that can effectively manage the infection, particularly when treated early. I don't doubt that environmental toxins and electromagnetic fields may increase our susceptibility to infection. But the Coronavirus itself can trigger a litany of autoimmune consequences if left unchecked--after 1-2 weeks when it has been left to run free..
Our governments and health officials have simply done every single thing wrong to manage it, greatly prolonging and worsening the situation. But you can successfully take your health into your own hands.
Find a doctor ahead of time who will treat you with effective antivirals so you will be prepared if you do develop symptomatic disease. Keep up the Vitamin D and Zinc and hopefully you will be an asymptomatic case who develops robust immunity. Find out if your state is one of about 25 that has restricted doctors or pharmacies from providing you with chloroquine drugs, and how to manage the situation.
For example, in my state of Maine, the governor has made prophylactic treatment illegal--but treatment once you get Covid is approved for up to 14 days as an inpatient or outpatient. Forewarned is forearmed! Connect with a medical partner now. Work together to create a treatment plan so you will receive your preferred, optimal treatment if you do become ill.
Monday, February 1, 2021
https://anthraxvaccine.blogspot.com/2021/02/again-is-virus-real.html
Is the Virus Real?
I continue to be asked if the virus is real. I answered this question in 2 prior blog posts, below. But Off-Guardian has a new article claiming the virus is fake, and I was again asked to comment.
https://anthraxvaccine.blogspot.com/2020/10/the-testing-mess-lack-of-reliable-data.html
https://anthraxvaccine.blogspot.com/2021/01/is-virus-real-has-it-been-photographed.html
Here is a description of its culture and isolation, with additional details in the supplementary materials, for those who continue to clamour for it
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228321/
Since I have explained some technical aspects in the two prior posts, I will be brief. Please read John McGowan's comment to the second post for greater detail, which helps debunk the Off-Guardian article.
1. There has been tremendous falsification of information on almost every aspect of the pandemic. I don't think there is much question about that, and I understand that it makes people appropriately suspicious about the reality of the virus, too. Particularly when people with MDs and PhDs after their names claim it does not exist.
2. I am willing to go on record to say that Andrew Kaufman, MD (a psychiatrist, not a molecular biologist, who got his undergrad degree in the same department I did at MIT--Biology) who is quoted in the piece, is wrong and ignorant, besides. As are others.
3. Here is the key argument: I have challenged those who deny Covid is caused by a real virus to explain what, exactly, is causing these symptoms if it is not a virus. One suggested toxins. Or 5G.
Well, toxins and 5G and exosomes are not contagious, but this disease is.
It has a very predictable incubation period, averaging 6 days.
Properly used PPE protects the wearer from exposure.
It causes mostly similar syndromes in those who get very ill.
The syndrome, while relatively unique, is similar to that caused by SARS-1 in 2003.
The illness responds well to antiviral drugs. Patients get better quickly when viral-killing protocols, including hydroxychloroquine or ivermectin, are used early in the illness.
These simple facts, along with the arguments I have made in the two linked blog posts, confirm that we are facing an infectious disease, and it is caused by a virus.
4. Hundreds of thousands of whole genome sequences (maps of every nucleotide in the virus' RNA) have been uploaded by scientists in scores of countries to international databases, each with its own local mutations. You would need to isolate and grow these viruses in order to sequence them. Saying that all these sequences are false requires that thousands of scientists are lying, together, about the work they have done. Since these scientists are from the US, China, Russia, and everywhere else, getting them all to tell the same lie would not be simple.
5. Did this virus originate in a lab? Almost certainly. Was it spread deliberately? I don't know. It could have been accidental. If it was spread deliberately, who did it? I don't know that either.
If you approach this question by asking who had the means, motive and opportunity to commit such a crime, we can at least begin the discussion.
a. Means: Scientists in multiple countries, including the US and China, had the means to produce a virus like this.
b. Motive: who is benefiting from the pandemic? The $US dollar, Amazon, Elon, Facebook, Zoom, Twitter and the surveillance state, for a start.
c. Opportunity: Since the world military games were held in Wuhan in October, military staff from dozens of countries had the opportunity. Wuhan is also an international trading center. Maybe anyone visiting Wuhan last fall had an opportunity.
If this theory is so easy to debunk, why does it keep popping up? I am starting to wonder if it isn't a psyop, repeatedly inserted into the discourse to stop people from looking into the true origin of the virus... looking into the funders of Gain of Function research on coronaviruses at NIAID and elsewhere... and looking into what exactly they were trying to do, and for whom...
Those are the important questions, particularly in terms of avoiding a repeat lab-derived pandemic.
Please don't waste any more of your time on the "fake virus" hypothesis. We don't have the time or luxury to fight each other. We need all hands on deck to turn back the Great Reset (whatever it is supposed to be) and regain sane control of our societies.
SARS-Cov-2 is a pathogen made by a computer , so simply computer code and only a part portion of what people think represents the genome of the Covid-19 causing virus as NO actual virus has been isolated and identified from an individual clinically determined to be suffering from the illness called Covid. The reference used with the RT-PCR process is nothing more than computer code 'BELIEVED' to represent the real genetic string.
No one can suffer an illness caused by a part string of computer generated and created code. So look at other sources of the illness conditions which appear as no different to most Flu like symptoms. Fever is the natural way along with inflamation to rid the body of materials it needs to.
The papers you cited claim that they have worked out the entire genetic structure of viruses such as “SARS-CoV-2” and uploaded this onto databanks, as Peng Zhou Zheng Li, Pilailuk, and their teams did, and as many have done since. Again, they claim that they have an “isolate” of the virus but this declaration is made after they have “constructed” the genome from their mixed brew containing genetic fragments of unknown provenance.
The process used to claim “isolation” can be summarised as follows. From the biological “soup” taken from patient’s lungs or nose swabs containing all sorts of material from the human subject, innumerable commensal microbes and potential contaminants, de novo assembly platforms search for short genetic fragments. After finding millions of unique fragments in the brew, these software programmes piece together a “genome” (one long piece) based on parameters set in the programme. Along the way there is a bit of cut-and-pasting and if pieces are “missing”, other ready- made templates can be added to fill the gaps. However, the man-made algorithms, probability models and arbitrary selections cannot deliver the “yes” or “no” answer to the question of its physical existence in nature, not least because any coronavirus “genome” used as a template in its production will likewise be propositional, the methodology providing no confirmable connection with the material or physical universe, making the new member of the Coronavirus genus merely another product of virology’s sui-referential processes.
An analogy for these processes would be that you find a million cards on the floor, each with partial sentences. You start arranging them into full sentences and then eventually a story. If some bits don’t fit you discard them, and if bits seem to be missing you borrow a paragraph from another story. But how would you know that this was an existing story and not something you had just made up? And why could there not be ten smaller stories in there, or no story at all? In short, you cannot claim to know the story unless you have access to the complete story before you start. And herein lies the cited papers deception – the teams did not work with a complete genome because they did not work with a complete virus. They worked with random bits of biological material and then tell us that it constitutes evidence of a virus. However, upon close examination of the methodologies employed, we can see that there’s a problem: there is no material proof of any virus.
The cited papers typify huge issues: what the public is not told is that no virus called SARS-CoV-2 has ever been actually isolated and purified as a whole unique structure. What takes place in the cited and many other papers is simply the shotgun sequencing of crude samples which contain genetic fragments of unknown provenance. Therefore, there is no evidence whatsoever, not even the vaguest guarantee, that the resulting in silico “genome” exists in nature or has anything to do with a “virus”. In this manner, however, the invention of the “virus” is presented as a discovery, its faux status retroactively secured through the act of denotation whereby its naming purports its prior existence and its pathogenicity.
That a notional hypothetical genome invented by such anti-science should lie at the heart of this assault on humanity is a scientific and ethical outrage. It is this false science that has turned the world upside-down, providing opportunity for politicians to assume the role of needle Nazis. That is the insidiousness of virology’s crime, a generalised version of the false claim of isolation provides politicians with “permission” to state-rape those in the government’s employ, and to extend their systematic programme of bodily violation into the private sector, and schools.
How contemporary democracies could have fallen for such preposterous but deadly nonsense is mind blowing.